|
KMID : 0363320030240010001
|
|
Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.1 ~ p.10
|
|
|
The Steroid Sparing Effects of Cheongsangboha-tang in Asthmatic Patients
|
|
Hwang Woo-Suck
Choi Jun-Yong
Lee Jae-Seung
Ju Chang-Yeop
Jung Doo-Young
Rhee Hyung-Koo
Jung Sung-Ki
|
|
|
Abstract
|
|
|
Background : In recent years, the glucocorticoid hormone has become a fundamental medication for asthma. However, a long period of hormone administration will result. in general. side effects on many body parts as well as hormone dependence, which has become a serious problem for western physicians.
Objectives : We aimed to identify the clinical effects of Cheongsanghoha-tang and the steroid sparing effects of Cheongsanghoha-tang on.
Materials and Methods : A subject group consists of 36 asthmatics who had been treated with Cheongsanghoha-tang for four weeks. Cheongsanghoha-tang is a herbal decoction, which has been used of the traditional therapeutic agent of asthma. PFT, QLQAKA, blood eosinophil, serum IgE, Serum IL-4. IL-5, IFN-{gamma} were checked before and 4weeks after the treatment.
Results : The only FVC% in ICSG among asthmatic patients was increased significantly compared to NICSG. Treatment of Cheongsanghoha-tang for four weeks resulted in significant increase in QLQAKA. The NICSG treated with Cheongsangboha-tang for four weeks were no significant difference in the blood eosinophil, serum IgE, IL-4 and IL-5. The PFT and QLQAKA in NICSG were increased significantly after 4 weeks treatment. But the serum IFN-{gamma} in NICSG was decreased significantly after 4 weeks treatment. Discontinuation of treatment with inhaled corticosteroid in ICSG resulted in insignificant changes in PFT, the blood eosinophil, the serum IgE, IL-4, IL-5 and IFN-{gamma} and significant increase in QLQAKA. As a result. 8 of 13 cases were cured with hormones completely and the rest of ICSG reduced the dose of ICS.
Conclusions : This study shows that Cheongsanghoha-tang has the effects on the improvement of pulmonary function and cures asthmatic patients. These findings demonstrate that Cheongsanghoha-tang has the steroid sparing effect. Some satisfactory therapeutic results have been obtained in treating hormone-dependent asthma by Cheongsanghoha-tang. However. the concept and mechanism of hormone-dependent asthma have not been fully defined yet, and the standard for judging therapeutic effects have not been established. Obviously further researches concerning all these are still necessary.
|
|
|
KEYWORD
|
|
|
Cheongsangboha-tang(Qingshangbuxia-tang), asthma, steroid sparing effect, cytokines
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|